Day + 30 detection of minimal residual FLT3-ITD by high-sensitivity PCR-NGS predicts relapse risk and guides post-transplant maintenance in AML - PubMed
3 hours ago
- #HSCT
- #AML
- #FLT3-ITD
- Detection of minimal residual FLT3-ITD by high-sensitivity PCR-NGS at day +30 post-HSCT predicts relapse risk in AML patients.
- FLT3-ITD-positive patients had a higher cumulative incidence of relapse (40.3% vs. 18.8%, p = 0.001).
- FLT3 inhibitor maintenance therapy prevented relapses in FLT3-ITD-positive patients.
- FLT3-ITD-negative patients without high-risk factors showed limited benefit from maintenance therapy.
- The study supports individualized post-transplant maintenance therapy based on FLT3-ITD detection.