Multi-omics reveal vitamin D regulation of immune-gut microbiome interactions and tolerogenic pathways in inflammatory bowel disease - PubMed
4 hours ago
- #Vitamin D
- #Multi-omics
- #IBD
- A study applied multi-omics techniques to explore how vitamin D affects immune-gut microbiome interactions and tolerance pathways in patients with inflammatory bowel disease (IBD).
- After 12 weeks of vitamin D treatment, patients showed reduced disease activity and inflammatory markers, along with changes in IgA-bound and IgG-bound gut microbiota.
- Vitamin D altered the profiles of IgA-bound bacteria (increased Lachnospiraceae and Blautia) and IgG-bound bacteria (decreased Proteobacteria and Enterococcaceae).
- Treatment also increased B cell activating factor (BAFF) signaling, modified BCR and TCR clonotypes related to Ig-bound gut microbiota, and boosted α4β7+ B and T regulatory cells.
- The findings indicate that vitamin D promotes immune tolerance to gut microbiota in IBD patients.