Defining the vascular niche of human adipose tissue across metabolic states - PubMed
a day ago
- #vascular biology
- #single-cell RNA sequencing
- #metabolic disease
- The study focuses on the vascular niche of human adipose tissue across different metabolic states.
- Single-cell RNA sequencing of nearly 70,000 vascular cells from 65 individuals reveals seven canonical endothelial cell (EC) subtypes.
- A distinct population of ECs with mixed endothelial, mesenchymal, adipocytic, and immune transcriptional features is identified.
- Computational analyses and whole-mount imaging suggest these ECs emerge through endothelial-to-mesenchymal transition.
- Comparative analyses show inflammatory and fibrotic vascular signatures in obesity and type 2 diabetes.
- The research highlights the contribution of vascular dysfunction to metabolic disease progression.
- Funding was provided by multiple organizations including Lundbeck Foundation, Carlsberg Foundation, and Novo Nordisk Foundation.