The effector differentiation of TCRαβ+CD8αα+ intraepithelial lymphocytes is reciprocally regulated by BCL6 and BLIMP1 - PubMed
4 hours ago
- #intestinal homeostasis
- #immunology
- #TCR signaling
- CD8αα+TCRαβ+ intraepithelial lymphocytes (IELs) are crucial for intestinal homeostasis and host protection.
- Two distinct developmental stages identified: stem-like (BCL6, TCF1, CD160) and effector-like (granzyme B, Prdm1).
- Differentiation from stem-like to effector-like IELs is driven by TCR and IL-12 signaling.
- BCL6 and BLIMP1 have opposing roles in regulating IEL differentiation.
- Loss of BCL6 promotes effector-like IELs, increasing inflammation in DSS-induced colitis.
- BLIMP1 deficiency disrupts effector differentiation, reducing gut inflammation susceptibility.