m6A reader Ythdf proteins control retrotransposon B2 repeat expression and safeguard early embryo development - PubMed
a day ago
- #Ythdf proteins
- #retrotransposon B2 RNAs
- #early embryo development
- Ythdf2 and Ythdf3, but not Ythdf1, are essential for early embryo development in mice.
- All three Ythdf proteins mediate the decay of target transcripts, including maternal mRNAs, mid-preimplantation-activated transcripts, and retrotransposon RNAs.
- Retrotransposon B2 RNAs are primary targets of Ythdf proteins during early embryo development.
- Deficiency in Ythdf1-3 leads to accumulation of SINE/B2 RNAs, attenuating RNA polymerase II transcription.
- Ythdf1-3 deficiency also represses Pol III-driven B2 transcription, modulating RNA polymerase II activity near B2 loci.
- The Ythdf-SINE/B2-gene expression axis is crucial for embryogenesis.