Repeat expansion RNA elicits toxicity through hybrid G-quadruplexes with promoter DNA - PubMed
5 hours ago
- #RNA toxicity
- #transcriptional dysregulation
- #G-quadruplexes
- C9orf72 expanded G4C2 repeat RNA forms hybrid G-quadruplexes with CG-rich promoter regions.
- Hybrid G-quadruplexes impede RNA polymerase II activity.
- This process leads to global transcriptional dysregulation in C9orf72 amyotrophic lateral sclerosis patient-derived cells.