Akkermansia muciniphila primes lung-resident antiviral immunity via the gut-lung axis during SARS-CoV-2 infection - PubMed
4 hours ago
- #Akkermansia muciniphila
- #SARS-CoV-2
- #gut-lung axis
- Akkermansia muciniphila primes lung-resident antiviral immunity via the gut-lung axis during SARS-CoV-2 infection.
- SARS-CoV-2 infection disrupts gut microbiome diversity and enriches A. muciniphila in K18-hACE2 transgenic mice.
- Prophylactic administration of live A. muciniphila reduces weight loss and improves lung pathology in infected mice.
- A. muciniphila enhances local antiviral immune responses in the lung without excessive systemic inflammation.
- Treated mice show elevated Th2 and Th17 cytokines, expansion of tissue-resident memory T cells, and iBALT formation.
- A. muciniphila serves as both a biomarker of COVID-19-related gut dysbiosis and a potential biotherapeutic for respiratory infections.