Unveiling the association between low-density lipoprotein cholesterol lowering and fracture risk : real-world evidence from a target trial emulation study - PubMed
4 days ago
- #statin therapy
- #LDL-C
- #fracture risk
- Study explores the association between lowering LDL-C levels and reduced fracture risk in individuals with hyperlipidaemia.
- A population-based cohort study of 165,242 individuals initiating statins showed lower five-year hip fracture risks in groups achieving LDL-C levels of 1.8-2.6 mmol/L (0.53%) and <1.8 mmol/L (0.52%) compared to >2.6 mmol/L (0.65%).
- Hazard ratios indicated significant risk reductions for hip fractures in lower LDL-C groups (HR=0.77 for 1.8-2.6 mmol/L; HR=0.68 for <1.8 mmol/L).
- Similar reductions were observed for recurrent hip fractures, composite fractures, and major osteoporotic fractures.
- Findings suggest that greater LDL-C reduction correlates with lower fracture risk, supporting a 'lower is better' approach for fracture prevention in hyperlipidaemia.