SPT6 maintains epidermal homeostasis by inhibiting an NF-κB-positive feedback loop to prevent excessive inflammation - PubMed
3 hours ago
- #SPT6
- #skin inflammation
- #NF-κB signaling
- SPT6 in basal keratinocytes prevents psoriasis-like skin inflammation by inhibiting NF-κB signaling.
- Loss of SPT6 causes epidermal hyperplasia, immune infiltration, and delayed wound healing via impaired Wnt signaling.
- SPT6 binds to the RELA gene enhancer to block a positive feedback loop, maintaining epidermal immune quiescence.