Activated Platelet-Released Heat Shock Protein 90α Triggers Autophagy-Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis - PubMed
4 hours ago
- #NET formation
- #sepsis
- #HSP90α
- Platelet-released HSP90α plays a key role in neutrophil extracellular trap (NET) formation during sepsis.
- HSP90α is increased in platelets from sepsis patients and is released in free and exosome-associated forms upon platelet activation.
- Extracellular HSP90α binds to TLR4 on neutrophils, activating the MyD88-Beclin 1 pathway, leading to autophagy-dependent NET formation.
- Blocking HSP90α with a neutralizing antibody reduces NET formation, thrombosis, and inflammation in sepsis models.
- This pathway provides new therapeutic targets for managing coagulation and organ failure in septic patients.