Progress in the development of cytokine armoured CAR T cells - PubMed
5 days ago
- #immunotherapy
- #cytokines
- #CAR T cells
- CAR T cell engineering has advanced from first-generation to fourth-generation armoured CAR T cells.
- Fourth-generation CAR T cells co-express cytokines, chemokines, or immunomodulatory factors to enhance efficacy, safety, and persistence.
- These advanced CAR T cells aim to reverse immunosuppression, potentially enabling treatment of solid tumours.
- The article discusses clinical and preclinical findings on cytokine-enhanced CAR T cells.
- Strategies for conditional cytokine secretion are explored to reduce systemic toxicity.