Proteogenomic characterization delineates clinically relevant subtypes of advanced differentiated thyroid cancer - PubMed
5 days ago
- #thyroid cancer
- #precision medicine
- #proteogenomics
- Proteogenomic analysis of 113 advanced differentiated thyroid cancers (DTC) identified three molecularly distinct subtypes: canonical, stromal, and immunogenic.
- Each subtype exhibits differences in driver mutations, histopathological features, and clinical outcomes, suggesting distinct therapeutic strategies.
- A machine learning classifier was developed to predict these subtypes using routinely available gene mutation and digital pathology data.
- The biological relevance of the classification was confirmed in an independent cohort analyzed by single-cell and spatial transcriptomics.
- Analysis of a real-world cohort receiving various systemic therapies provides preliminary clinical evidence supporting the utility of this subtyping framework for treatment decisions.
- The study offers a rationale and practical tool for personalized treatment in advanced DTC.