CBX6 and CA9 as predictive indicators and therapeutic targets in GBM - PubMed
4 hours ago
- #Hypoxia
- #Glioblastoma
- #Therapeutic Targets
- CBX6 downregulation under hypoxia correlates with higher-grade GBM and worse survival, acting as a negative regulator of tumor aggressiveness.
- CA9 upregulation under hypoxia promotes an acidic tumor microenvironment, aggressive GBM phenotype, and treatment resistance.
- CBX6 binds to the CA9 promoter, inversely regulating CA9 expression, highlighting both as potential therapeutic targets in GBM.