Atractylodin ameliorates obesity-associated hepatic steatosis by regulating the PLIN2-ATGL/CPT1A axis-mediated lipid droplet-mitochondria interactions - PubMed
4 hours ago
- #Hepatic Steatosis
- #Atractylodin
- #Lipid Metabolism
- Atractylodin (ATR), from Atractylodes lancea, improves obesity-related hepatic steatosis by enhancing lipid droplet-mitochondria interactions.
- ATR works by regulating the PLIN2-ATGL/CPT1A axis, promoting lipolysis and fatty acid oxidation in liver cells.
- In high-fat diet-induced mice and FFA-treated cell models, ATR reduced lipid accumulation and increased LD-mitochondria contacts.