The Plasmodium falciparum PPCS is a unique heteromeric complex with prokaryote-like activity and is a target of pantothenate analogs - PubMed
3 hours ago
- #CoA biosynthesis
- #malaria
- #drug target
- The Plasmodium falciparum PPCS is a unique heteromeric complex with prokaryote-like activity.
- PfPPCSs form a functional complex that uniquely cannot use adenosine 5'-triphosphate.
- The complex is a target for antiplasmodial pantothenate analogs.
- Study highlights potential for designing inhibitors that exploit PfPPCS's unique features.
- Findings could lead to new therapies for malaria by targeting CoA biosynthesis.