NADPH oxidase-1 suppression prolongs the antidepressant-like effect of ketamine - PubMed
4 hours ago
- #ketamine
- #NOX-1
- #antidepressant
- Ketamine produces rapid antidepressant effects in treatment-resistant depression (TRD), but its benefits are short-lived.
- A novel AMPAR positive allosteric modulator, K-4, showed more sustained antidepressant-like effects than ketamine in Wistar Kyoto rats.
- RNA sequencing revealed lower NADPH-oxidase-1 (NOX-1) expression in the medial prefrontal cortex (mPFC) of K-4-treated rats compared to ketamine-treated rats.
- NOX-1 inhibition prolonged ketamine's antidepressant-like effects and reduced burst firing in the lateral habenula (LHb).
- NOX-1 knockdown in the mPFC sustained ketamine's effects and suppressed LHb bursting activity, suggesting NOX-1 as a target for TRD maintenance strategies.