Hepatoprotective role for ERMP1 in MASLD-driven hepatocarcinogenesis and β-catenin-mutated tumors - PubMed
3 hours ago
- #ERMP1
- #HCC
- #lipid-metabolism
- ERMP1 is upregulated in MASLD and HCC, correlating with advanced stage and poor survival.
- ERMP1 knockout or silencing in models showed dual roles: increased tumor burden in lipid-dependent and Myc/β-catenin-driven HCC but reduced tumorigenesis in Myc/p53-driven and DEN-induced HCC.
- Ermp1 deficiency worsened diet-induced steatosis and elevated HDL cholesterol, affecting lipid metabolism.
- Proteomics revealed Ermp1 loss depletes DNA repair and structural proteins while enriching cholesterol transport and bile acid pathways.
- In vitro, ERMP1 silencing impaired HCC cell adhesion/migration, triggered apoptosis, and increased chemotherapy sensitivity.
- ERMP1 has a protective role in MASLD and β-catenin-driven HCC but may support tumor progression post-transformation.