M1 macrophage-derived migrasomes exacerbate post-myocardial infarction injury via guanylate binding protein 5 - PubMed
2 hours ago
- #Myocardial Infarction
- #Migrasomes
- #Macrophages
- M1 macrophage-derived migrasomes (M1-Migs) exacerbate post-myocardial infarction (MI) injury.
- Guanylate binding protein 5 (GBP5) is highly expressed in M1-Migs and mediates their harmful effects.
- GBP5 activates NF-κB signaling, promoting myocardial cell apoptosis.
- Clinical samples show a positive correlation between macrophage-derived migrasomes and MI severity.
- Colchicine may reduce post-MI injury by inhibiting migrasome production in M1 macrophages.