Intradermal Delivery of Catalase via Extracellular Vesicles for Targeted Photoaging Therapy - PubMed
4 hours ago
- #photoaging therapy
- #extracellular vesicles
- #catalase delivery
- Engineered 313 cell line to produce catalase-loaded extracellular vesicles (313EVs) with high efficiency and preserved enzymatic activity.
- 313EVs enriched in pathways related to EV uptake, mitochondrial membrane recovery, and DNA repair, aiding in photoaging mitigation.
- 313EVs alleviated oxidative stress and restored antioxidant capacity in UVB-damaged fibroblasts.
- Intradermal administration of 313EVs led to sustained catalase activity, improved skin elasticity, and reduced wrinkles.
- Therapeutic efficacy of 313EVs was independent of skin microbiota, indicating intrinsic vesicle mechanisms.
- 313EVs demonstrated potential as a versatile protein-delivery platform for oxidative stress-driven skin aging.