Targeting microbiota-generated acetaldehyde to prevent progression of metabolic dysfunction-associated steatotic liver disease - PubMed
4 hours ago
- #probiotics
- #microbiome
- #liver-disease
- Excessive dietary sugar, especially fructose, worsens liver disease by increasing gut microbiota-produced acetaldehyde.
- UK Biobank data (210,000+ participants) shows sugar intake correlates with liver-related mortality and microbial shifts favoring acetaldehyde pathways.
- Gut-derived acetaldehyde activates hepatic stellate cells via MMP7 upregulation, promoting liver fibrosis.
- Engineered probiotic *Ligilactobacillus salivarius* HAM degrades acetaldehyde, halting fibrosis in preclinical liver disease models.
- Targeting microbiota-driven acetaldehyde metabolism may prevent MASLD-to-MASH progression.