TMEM145 is a principal component of outer hair cell stereocilia - PubMed
5 hours ago
- #Stereocilia Proteins
- #Hearing Loss Mechanisms
- #Cochlear Amplification
- TMEM145 is identified as a core component of the tectorial membrane attachment crowns (TM-ACs) in outer hair cell stereocilia.
- It localizes to the tips of the tallest stereocilia row, similar to tubby and stereocilin.
- Genetic deletion in mice leads to loss of tubby and stereocilin, stereocilia detachment from the tectorial membrane, severe hearing loss, and impaired cochlear amplification.
- TMEM145 binds cytoplasmic tubby and anchors secreted stereocilin via its extracellular Golgi-like domain.
- The findings suggest TMEM145 and related GOST proteins organize transmembrane anchor complexes.