DNA electroporation of HIV Env elicits robust T cell responses and memory B cell responses with muted serum antibody levels that can be boosted with recombinant protein - PubMed
4 hours ago
- #Clinical trial
- #DNA electroporation
- #HIV-1 vaccine
- DNA electroporation of HIV Env elicits robust T cell and memory B cell responses but muted serum antibody levels.
- A phase 1 clinical trial (HVTN 304) evaluated a synthetic DNA-encoded HIV-1 Env trimer with IL-12 DNA adjuvant, delivered via intradermal electroporation.
- The regimen did not induce autologous neutralizing antibodies but did induce binding antibodies in over half of DNA-only participants and all boosted participants.
- Env-specific CD4+ T cells were detected in all participants, with CD8+ T cells in up to 75%.
- The study suggests DNA vaccination combined with a heterologous boost may be a viable modality for iterative HIV-1 vaccine testing.