ONC206 demonstrates potent anti-tumorigenic activity and is a potential novel therapeutic strategy for high-risk medulloblastoma - PubMed
a day ago
- #ClpP
- #Medulloblastoma
- #ONC206
- ONC206 shows strong anti-tumor effects in high-risk medulloblastoma.
- ONC206 activates mitochondrial ClpP, leading to cancer cell apoptosis.
- High ClpP expression found in medulloblastoma tumors vs. normal brain tissue.
- ONC206 reduces viability in Group 3, Group 4, and SHH-driven medulloblastoma cells.
- Treatment induces integrated stress response and mitochondrial damage.
- ONC206 significantly extends survival in murine models and PDX-bearing mice.
- ONC206 is a promising novel therapy for high-risk medulloblastoma patients.