Evaluation of 334 Pediatric CNO Cases: A Multicenter Cohort Study Defining Clusters - PubMed
3 hours ago
- #Pediatric Rheumatology
- #Chronic Non-Bacterial Osteomyelitis
- #Cluster Analysis
- Multicenter cohort study evaluating 334 pediatric CNO cases in Turkey.
- Identified four distinct clusters based on bone-site involvement: Axial-thoracic, lower-extremity, and others.
- Axial-thoracic cluster more common in females with higher skin involvement.
- Lower-extremity cluster was the largest group.
- Turkish cohort showed male predominance and lower skin involvement compared to previous reports.
- 77.3% achieved remission at 42.4 months median follow-up; 22% experienced relapse.
- Mandibular involvement, additional rheumatologic diseases, and localized bone pain increased relapse risk.
- Findings may help guide prognosis and require validation in other populations.