Melatonin alleviates airway inflammation and anxiety-depression in asthma via gut microbiota-SCFA axis-mediated inhibition of microglial activation - PubMed
4 hours ago
- #gut-brain axis
- #melatonin
- #asthma comorbidity
- Melatonin and sodium butyrate reduce airway inflammation and improve lung function in a mouse asthma model.
- They also alleviate anxiety- and depression-like behaviors in asthmatic mice by increasing gut-derived butyrate and restoring microbiota balance.
- Fecal microbiota transplantation from treated mice replicates benefits, while antibiotic depletion blocks melatonin's effects, showing gut microbiome involvement.
- Mechanism involves inhibition of the MAPK/P65/NLRP3 signaling pathway in hippocampal microglia, reducing microglial activation.