Voluntary wheel running exercise attenuates VPA-induced ASD-like behaviors in male rats: implication of the vagal pathway of the gut-brain axis - PubMed
4 hours ago
- #Exercise Therapy
- #Autism Spectrum Disorder
- #Gut-Brain Axis
- Voluntary wheel running exercise reduces ASD-like behaviors in male rats induced by VPA.
- Exercise restructures gut microbiota and increases SCFA levels, particularly butyrate.
- Exercise normalizes neuroactive substances in the hippocampus and prefrontal cortex.
- Exercise reduces neuroinflammation and shifts microglial polarization to an anti-inflammatory state.
- Subdiaphragmatic vagotomy blocks exercise-induced improvements, indicating the vagal pathway's role.
- The study suggests the gut-brain axis, via the vagal pathway, mediates exercise benefits for ASD.