Exosome-Based Diagnostics and Cell-Free Therapeutics for Traumatic Brain Injury: From Mechanisms to Bedside - PubMed
4 hours ago
- #Traumatic Brain Injury
- #Cell-Free Therapy
- #Exosomes
- Traumatic Brain Injury (TBI) is a leading neurological disorder with complex mechanisms and variability.
- Exosomes, a type of extracellular vesicle, show promise in TBI diagnosis and treatment due to their biocompatibility and ability to cross the blood-brain barrier.
- Exosomes regulate inflammation, neuronal repair, vascular changes, and cognitive function post-TBI.
- They serve as novel biomarkers for early diagnosis and prognosis assessment of TBI.
- Exosome tissue engineering applications in TBI are summarized, including preclinical translational basis.
- Challenges include standardization of isolation procedures, safety, and long-term efficacy.
- Exosomes offer a new paradigm for cell-free therapy and precision diagnosis in TBI.