Hydroxy Safflower Yellow A: A Natural Compound from Carthamus tinctorius L. with Potent Activity Against Liver Fibrosis and Cancer - PubMed
4 hours ago
- #Liver Fibrosis
- #Natural Compounds
- #Hepatocellular Carcinoma
- Hydroxy Safflower Yellow A (HSYA) is a natural flavonoid from Carthamus tinctorius L. with potential against liver fibrosis and cancer.
- HSYA combats liver fibrosis by reducing oxidative stress, inflammation, and modulating hepatic stellate cells via pathways like PPARγ/p38 MAPK and TGF-β1/Smad3.
- In hepatocellular carcinoma (HCC), HSYA induces apoptosis, regulates autophagy, and inhibits tumor invasion through PI3K/Akt/mTOR and NF-κB pathways.
- HSYA is a multi-target compound that effectively blocks the progression from liver fibrosis to HCC.
- The review synthesizes in vitro and in vivo studies from PubMed, Google Scholar, and CNKI to highlight HSYA's mechanisms.