Pathogenic Role of SERPINB3-positive Neutrophils in Reinforcing Thrombus Stiffening during Ischemic Stroke - PubMed
3 hours ago
- #thrombus stiffening
- #ischemic stroke
- #SERPINB3
- Neutrophils are the dominant immune cell population in human stroke thrombi.
- Neutrophils positively correlate with collagen, increased thrombus stiffness, and poorer clinical outcomes.
- SERPINB3, a neutrophil-enriched protein, is strongly linked to poor prognosis in ischemic stroke.
- Neutrophil-derived SERPINB3 promotes early thrombus formation and enhances collagen deposition in murine models.
- SERPINB3 amplifies thrombus stiffness via TGFβ1 upregulation, neutrophil extracellular traps, and COL1A1.
- Targeted SERPINB3 knockdown improves thrombolysis efficiency and neurological recovery in models.
- SERPINB3 is identified as a prognostic biomarker and potential therapeutic target in acute ischemic stroke.