Dynamic glucose-responsive mesoporous silica nanoparticle coating on trabecular tantalum implants for dual mode drug delivery - PubMed
7 hours ago
- #Diabetic osseointegration
- #Smart biomaterials
- #Glucose-responsive drug delivery
- Development of a trabecular tantalum implant with a porous structure mimicking cancellous bone mechanics.
- Coating with phenylboronic acid-modified mesoporous silica nanoparticles loaded with aspirin for dynamic, glucose-responsive, dual-mode drug delivery.
- Under normoglycemia, aspirin is released slowly to promote osteogenesis; under hyperglycemia, release is accelerated to suppress inflammation.
- In vitro, the coating enhanced osteogenic differentiation of stem cells and promoted M2 macrophage polarization.
- In a diabetic rat defect model, the system improved osseointegration and reduced inflammatory responses.
- The strategy addresses impaired osteogenesis and inflammation in diabetes, advancing smart biomaterials for clinical translation.