The Gut-Extracellular Vesicle-Mitochondria Axis in Reproductive Aging: Antioxidant and Anti-Senescence Mechanisms - PubMed
3 hours ago
- #mitochondria
- #gut microbiome
- #reproductive aging
- Cellular senescence, mitochondrial dysfunction, and oxidative stress contribute to reproductive aging.
- Systemic factors like gut microbiome metabolites and extracellular vesicles (EVs) play a key role in reproductive aging.
- EVs transport antioxidant enzymes, microRNAs, and bioactive lipids that regulate mitochondrial function and inflammation.
- Gut microbiome metabolites enhance mitochondrial quality control and activate antioxidant pathways.
- A gut-EV-mitochondria axis is proposed as a framework affecting gamete competence and reproductive longevity.
- Potential therapeutic strategies include microbiome modulation, EV-based interventions, and senotherapeutics.