Measuring signatures of host resistance, disease tolerance, and damage in human sepsis: a prospective cohort study - PubMed
3 hours ago
- #biomarkers
- #mortality
- #sepsis
- The study measured protein biomarkers aligned with host resistance to infection, disease tolerance, and damage in 444 adults with community-onset sepsis.
- Greater host damage was significantly associated with increased 90-day mortality, while host resistance and disease tolerance were not.
- Sepsis subtypes showed pronounced differences: δ‑type patients had higher damage and lower tolerance, whereas α‑type patients had lower damage and higher tolerance.