Ginsenoside Rg1 alleviates MASH by targeting GLS2 to enhance PINK1/Parkin-mediated mitophagy and improve mitochondrial function - PubMed
3 hours ago
- #MASH
- #Mitophagy
- #Ginsenoside Rg1
- Ginsenoside Rg1 (G-Rg1) alleviates Metabolic dysfunction-associated steatohepatitis (MASH) by enhancing mitophagy and improving mitochondrial function.
- G-Rg1 targets glutaminase 2 (GLS2), activating the GLS2/PINK1/Parkin pathway to promote mitophagy.
- Treatment with G-Rg1 reduces hepatocellular lipid accumulation, oxidative stress, and restores mitochondrial function in MASH.
- GLS2 overexpression mimics the protective effects of G-Rg1, suggesting GLS2 as a therapeutic target for MASH.
- The study combines histological, biochemical, and molecular docking analyses to confirm G-Rg1's mechanism of action.