Mfi2: an outer mitochondrial membrane mitofissin required for mitophagy - PubMed
3 days ago
- #mitophagy
- #mitochondrial fission
- #mitofissin
- Mitophagy selectively eliminates damaged or excess mitochondria to maintain mitochondrial homeostasis.
- Mitochondria need to be fragmented for sequestration within autophagosomes during mitophagy.
- Dynamin-related fission factors (Dnm1 in yeasts, DNM1L/DRP1 in mammals) are dispensable for mitophagy.
- Atg44, a mitochondrial intermembrane space protein, is identified as a mitofissin involved in mitochondrial fission during mitophagy.
- Mfi2, a mitochondrial outer membrane-resident mitofissin, is required for efficient mitophagy and acts independently of Dnm1.
- Mitophagy-associated mitochondrial fission is driven by mitofissins acting from both inner and outer mitochondrial membranes.
- Remaining issues include regulation of mitofissin activities and modulation by mitochondrial lipids like cardiolipin.