Functional and metabolomic analyses of brown adipose tissue during cold-deacclimation reveal rapid N-acetylated amino acid adaptations - PubMed
4 hours ago
- #brown adipose tissue
- #thermogenesis
- #metabolomics
- Non-shivering thermogenesis (NST) in brown adipose tissue (BAT) is activated in cold conditions and inactive in warm environments.
- Mice acclimated to 4°C for 7 days and then deacclimated at 30°C showed a 40% immediate decrease in metabolic rates and food intake.
- Uncoupled respiration decreased by 24 hours, with gradual declines in mitochondrial protein content and UCP1 gene expression.
- Metabolomic profiling revealed significant changes in amino acid, TCA cycle, glutathione, and purine metabolism pathways.
- Decreases in N-acetylated amino acids during cold deacclimation correlated with increased aminoacylase 1 (Acy1) expression.
- The study highlights coordinated structural and metabolic remodeling of BAT mitochondria during thermogenesis and deactivation.