4-Hydroxybenzyl Alcohol Mitigates Hyperlipidemia-Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF-κB Pathway - PubMed
2 days ago
- #depression
- #hyperlipidemia
- #neuroinflammation
- 4-Hydroxybenzyl alcohol (4-HBA) mitigates hyperlipidemia-associated depression by inhibiting neuroinflammation via the NKIRAS2/NF-κB pathway.
- Hyperlipidemia is linked to increased depression susceptibility, and 4-HBA improves lipid metabolism and alleviates depression-like behaviors in high-fat diet-fed mice.
- 4-HBA inhibits NF-κB activation through NKIRAS2, reducing inflammatory responses in LPS-stimulated BV2 cells and enhancing neuronal viability in HT22 neurons.
- Silencing NKIRAS2 negates the anti-inflammatory and neuroprotective effects of 4-HBA, confirming the pathway's role.
- 4-HBA is identified as a dual-action metabolite that addresses both metabolic and psychiatric symptoms through neuroinflammatory regulation.