Discovery of an ITK and TRK kinase inhibitor for the potential topical treatment of atopic dermatitis - PubMed
2 days ago
- #topical treatment
- #atopic dermatitis
- #kinase inhibitor
- Discovery of PF-07245303, a compound inhibiting ITK and TRK kinases for potential topical treatment of atopic dermatitis.
- PF-07245303 reduces production of interleukin-4 and interleukin-13, key drivers of atopic dermatitis, by inhibiting ITK.
- The compound also suppresses nerve growth factor-induced human basophil activation by inhibiting TRK family kinases.
- In human skin explants, PF-07245303 inhibits TRKA phosphorylation and suppresses cytokine expression from T cell receptor-activated resident T cells.
- Topical application of PF-07245303 reduces proinflammatory and epidermal changes in a dermatitis mouse model.
- The dual inhibition of pathogenic inflammatory mechanisms by PF-07245303 suggests therapeutic potential for atopic dermatitis patients.