Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or function in obese mice and humans - PubMed
3 hours ago
- #GLP-1
- #obesity
- #muscle mass
- GLP-1 medicines primarily reduce body fat in obese mice with a minor decrease in lean body mass (LBM).
- Liver mass loss exceeds muscle mass reduction in obese mice treated with GLP-1 medicines.
- Absolute muscle mass and strength decrease, but relative muscle mass and strength improve, enhancing running performance.
- GLP-1 medicines affect the muscle proteome differently compared to calorie restriction during immobilization.
- Obese patients on GLP-1 medicines show improved body composition without negative impacts on strength.
- Middle-aged mice and humans on GLP-1 experience slight absolute muscle loss but better body composition and mobility.