Esketamine-Based Opioid-Free versus Opioid-Based Anesthesia for Recovery Quality After Laparoscopic Transabdominal Preperitoneal Repair: A Randomized Noninferiority Trial - PubMed
6 hours ago
- #postoperative recovery
- #anesthesia
- #noninferiority trial
- The study compared esketamine-based opioid-free anesthesia (OFA) versus opioid-based anesthesia (OBA) for recovery quality after laparoscopic TAPP repair.
- In a randomized noninferiority trial with 126 patients, OFA showed higher QoR-15 scores at 24 hours postoperatively than OBA.
- OFA was associated with lower pruritus incidence, reduced vasopressor use, and lower pain scores on coughing at 24 and 48 hours.
- Esketamine-based OFA was found noninferior to OBA, offering a safer alternative with fewer opioid-related complications.