Nanocascade Engineering Workshop for Synergistic Microenvironment Reprogramming and EpSC Revitalization in Precise Diabetic Wound Therapy - PubMed
3 hours ago
- #nanocascade engineering
- #microenvironment reprogramming
- #diabetic wounds
- Chronic diabetic wounds are characterized by impaired closure due to chronic inflammation and impaired regeneration.
- Poor proliferative and differentiative ability of epidermal stem cells (EpSCs) in an inflammatory microenvironment delays healing.
- A nanocascade engineering workshop (Cu5.4O@LL-37/pDNA) was designed to reshape the inflammatory microenvironment and activate EpSC functions.
- The core of the workshop is an ultrasmall Cu5.4O nanozyme that eliminates reactive oxygen species and enhances the inflammatory response.
- The shell is constructed from plasmid DNA (pDNA) and antibacterial peptide LL-37, improving gene transfection efficiency and inhibiting bacterial infection.
- The system improves gene delivery and sustains P311 expression, promoting EpSC proliferation and differentiation.
- This nanotherapy accelerates re-epithelialization and wound closure in diabetes and infection models.
- The treatment strategy offers a novel approach for durable and effective healing of chronic wounds.