Inflammatory pathways in atrial fibrillation: mechanisms and novel therapeutic targets - PubMed
6 hours ago
- #atrial fibrillation
- #therapeutic targets
- #inflammation
- Inflammation is a predisposing factor for atrial fibrillation (AF), the most common sustained cardiac arrhythmia.
- Systemic inflammatory disorders (like autoimmune disorders, diabetes, obesity) or local heart/pericardium inflammation are linked to AF.
- Inflammation triggers signaling pathways and proinflammatory cytokines, promoting structural and electrical changes in the atria, increasing AF susceptibility.
- Inflammation induces oxidative stress, autonomic nervous system imbalance, and enhances atrial or pulmonary vein arrhythmogenesis through electrophysiological and fibrotic modulation.
- This review explores pathophysiological links between inflammation and AF and identifies potential novel therapeutic targets.