Single-cell epigenomics uncovers heterochromatin instability and transcription factor dysfunction during mouse brain aging - PubMed
4 hours ago
- #epigenomics
- #heterochromatin
- #brain aging
- Single-cell epigenomics used to study chromatin accessibility and gene expression in mouse brain aging.
- Decline in progenitor populations involved in neurogenesis and myelination observed.
- Age-associated changes in transcription and chromatin accessibility found across neuronal and glial cell types.
- Dysregulation of master transcription factors and shift toward stress-response programs noted.
- Region- and cell-type-specific heterochromatin loss identified, particularly in glutamatergic neurons.
- Increased accessibility at H3K9me3-marked domains and activation of transposable elements reported.
- Upregulation of long noncoding RNAs observed during aging.
- Findings highlight disruption of heterochromatin maintenance and transcriptional regulation in brain aging.