Prognostic value of the fibrosis-4 index for predicting in-hospital mortality in sepsis patients: evidence from MIMIC-IV and eICU databases - PubMed
5 days ago
- #Sepsis
- #Mortality
- #FIB-4
- The Fibrosis-4 (FIB-4) index was evaluated for predicting in-hospital mortality in sepsis patients using MIMIC-IV and eICU databases.
- Elevated FIB-4 levels (>1.25) were significantly associated with higher in-hospital mortality (P < 0.001).
- FIB-4 outperformed traditional scores like SOFA and APACHE in prognostic discrimination.
- Kaplan-Meier curves showed reduced survival in high FIB-4 groups.
- Sensitivity analyses confirmed FIB-4's prognostic value even after excluding patients with pre-existing liver disease.
- FIB-4 is a practical tool for early risk stratification in ICU settings due to its simplicity and reliance on routine lab parameters.