TMEM259/MEMBRALIN is a non-canonical ER-phagy receptor that associates with MAN1B1 and VCP to eliminate viral glycoproteins - PubMed
2 days ago
- #viral glycoproteins
- #ER-phagy
- #autophagy
- TMEM259/MEMBRALIN is identified as a non-canonical ER-phagy receptor.
- It associates with MAN1B1 and VCP to eliminate viral glycoproteins.
- The TMEM259-MAN1B1-VCP axis targets viral glycoproteins like SARS-CoV-2 spike, EBOV glycoprotein, IAV HA, and HIV-1 envelope glycoprotein to lysosomes.
- This process occurs in a ubiquitin-independent manner.
- Misfolded host glycoproteins are cleared through ERAD or alternative ERLAD pathways.
- MAN1B1 may function as a glycan-density sensor, enabling TMEM259 to link ER proteostasis with antiviral immunity.
- The findings expand the understanding of selective autophagy and reveal a specialized ER-phagy pathway for viral glycoprotein elimination.