Dissecting the aberrant vasculature of glioblastoma: mechanisms and therapeutic targets - PubMed
3 days ago
- #Glioblastoma
- #Angiogenesis
- #Tumor microenvironment
- Glioblastoma (GBM) is a highly aggressive and incurable tumor of the central nervous system.
- The GBM microenvironment contains abnormal and heterogeneous blood vessels, forming a chaotic vascular network.
- Aberrant vessels disrupt oxygen and nutrient delivery and contribute to malignant invasion, immune evasion, and therapeutic resistance.
- The review discusses morphological and functional changes in GBM vasculature compared to the normal blood-brain barrier.
- Cellular and molecular mechanisms behind abnormal vessel formation and their role in tumor progression are highlighted.
- Current vascular-targeted therapies for GBM are reviewed, along with potential future clinical directions.