PRMT5 Methylates and Stabilizes EphA2 via Inhibiting Its Ubiquitination and Degradation to Promote Nasopharyngeal Carcinoma Stem Cell Properties - PubMed
19 hours ago
- #Nasopharyngeal Carcinoma
- #EphA2
- #PRMT5
- PRMT5 binds to EphA2 and methylates it at arginine 816, stabilizing EphA2 by inhibiting Cbl-mediated ubiquitination and degradation.
- PRMT5 promotes nasopharyngeal carcinoma (NPC) stem cell properties both in vitro and in vivo through methylating and stabilizing EphA2.
- A 20-amino acid PRMT5-derived peptide, P20, disrupts PRMT5-EphA2 interaction, degrades EphA2, and suppresses NPC stem cell properties.
- PRMT5 and EphA2 are overexpressed in NPC tissues, with combined expression offering better prognosis prediction than individual proteins.
- The findings suggest targeting EphA2 degradation via P20 as a potential therapeutic strategy against NPC stem cell properties.