Α-Ketoglutarate ameliorates appendicitis by modulating Gln metabolism and inhibiting NF - κB signaling pathway - PubMed
4 hours ago
- #acute-appendicitis
- #nf-kb-signaling
- #glutamine-metabolism
- α-Ketoglutarate (α-KG) improves appendicitis by regulating Glutamine (Gln) metabolism and inhibiting the NF-κB signaling pathway.
- Acute appendicitis involves dysregulated immune responses and metabolic disturbances, with current treatments limited by complications and recurrence risks.
- Inflamed appendiceal tissues showed downregulation of Gln catabolic genes (GLS1, GLUD1) and reduced α-KG levels, linked to NF-κB hyperactivation and cytokine storms.
- Exogenous α-KG supplementation in murine models suppressed p65 phosphorylation, stabilized IκBα, and reduced pro-inflammatory cytokines (IL-6, TNF-α), improving survival rates.
- Combined α-KG and antibiotic therapy showed synergistic effects, while Gln alone had limited benefits.
- Dysfunctional Gln metabolism contributes to appendicitis pathogenesis via NF-κB-mediated inflammation, with α-KG showing potential as an adjunctive therapy.