A bridge-like lipid transfer protein is critical for generation of invasive stages in malaria parasites - PubMed
3 hours ago
- #malaria
- #lipid transfer
- #membrane contact sites
- A bridge-like lipid transfer protein (PfVPS13L1) is essential for forming invasive stages in malaria parasites by facilitating bulk lipid transfer.
- PfVPS13L1 interacts with the ER adapter PfVAP at membrane contact sites, bridging the endoplasmic reticulum with the growing inner membrane complex (IMC).
- Loss of PfVPS13L1 function impairs IMC growth, leading to smaller anucleated progeny and disrupted schizogony, highlighting its role in parasite replication.