Betulin modulates the EGFR/JAK2/STAT3 pathway to alleviate cognitive impairment and microglia-mediated neuroinflammation in stroke mice - PubMed
4 hours ago
- #PSCI
- #Betulin
- #Neuroinflammation
- Betulin improves cognitive performance in stroke-induced mice.
- Betulin reduces microglial activation and neuroinflammation by decreasing TNF-α, IL-1β, and IL-6 levels.
- The EGFR/JAK2/STAT3 pathway is identified as a key mechanism for Betulin's effects.
- Disrupting Betulin-EGFR interaction reduces its inhibitory effect on the EGFR/JAK2/STAT3 pathway.
- Betulin may serve as a therapeutic candidate for post-stroke cognitive impairment (PSCI).