Genetic predisposition to coffee consumption and the association with the early risk of atherosclerosis - PubMed
3 hours ago
- #Atherosclerosis
- #Genetic Predisposition
- #Coffee Consumption
- Study investigates the association between coffee intake, genetic predisposition, and early risk of subclinical coronary and carotid atherosclerosis.
- Observational analysis found no significant link between coffee consumption and measures of atherosclerosis (SIS, CACS, carotid plaques).
- Mendelian randomization analyses showed genetic predisposition to higher coffee consumption is associated with increased SIS, indicating potential coronary atherosclerosis risk.
- Specific SNPs in AHR and CYP1A1/CYP1A2 genes correlated with SIS in individuals consuming coffee more than twice daily.
- Multi-omics analyses identified lipid-related metabolites and inflammation-related proteins linked to genetic proxy of coffee consumption.
- Findings suggest genetically influenced coffee consumption may elevate coronary atherosclerosis risk in frequent drinkers, though biological mechanisms remain unclear.